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Central catecholamine receptor blocking actions of BE-2254 ('heat'): comparison with chlorpromazine and haloperidol. |
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| Authors: | B V Clineschmidt A B Pflueger P R Bunting J C McGuffin R J Ballentine |
| Institution: | Merck Institute for Therapeutic Research, West Point, Pennsylvania 19486, U.S.A. |
| Abstract: | BE-2254, 2-beta-(4-hydroxyphenyl)-ethylaminomethyl]-tetralone, (ED50 = 3.4 mg/kg i.p.) was about equal to chlorpromazine (ED50 = 4.4) as an antagonist of central noradrenergic receptor stimulation produced by clonidine (enhancement of the flexor reflex in spinalized rats). Haloperidol and phentolamine had essentially no effect at 9 mg/kg i.p... |
| Keywords: | Norepinephrine receptor antagonist BE-2254 (‘HEAT’) Haloperidol Amphetamine Dopamine receptor antagonist Chlorpromazine |
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