乌审旗健康儿童麻疹减毒活疫苗免疫成功率监测结果分析

目的评价乌审旗健康儿童麻疹减毒活疫苗（MV）免疫效果，为免疫管理提供科学依据。方法分别取满8月龄儿童在接种MV前后血清标本，分别取1．5～2周岁儿童在复种州前后血清标本各82与32份，用酶联吸附法检测麻疹1gG抗体，抗体浓度（GMC）≥200IU／ml判断为阳性。结果初免前阳性率为2．94％（1／34），GMC为54IU／ml，免后阳性率为100．00％（34／34），GMC为1358IU／ml，为接种前的25倍：复种前阳性率为100．00％（82／82），其中低、中、高水平抗体阳性率分别占10．98％、79．27％和9．75％，GMC为1268IU／ml，复种后阳性率为100．00％（32／32），中、高水平抗体阳性率达100．00％，GMC为2344IU／ml，为复种前的1．85倍。结论在保持高WV接种率的前提下，免疫成功率的高低是控制麻疹发生的关键：初免后儿童应于1．5～2周岁进行复种，可进一步提高儿童的麻疹抗体。

Analysis of the surveillance results of the success rate of live measles vaccine for normal children

Objective The study was conducted to evaluate the immune effect of live measles vaccines（MV） for healthy children in WuShenqi,providing scientific evidence for immune management.Methods The serum samples of 8-month-old children before and after MV inoculation and 82 and 32 samples of 1.5 -and 2-year-old children before and after the re-inoculation were respectively collected for the detection of measles lgG antibodies with ELISA.Antibody titers（GMC） ≥200 IU/ml was judged as positive Results The positive rate before the initial was 2.94%（1/34）, GMC being 54IU/mlo The positive rate after re-inoculation was 100.00%（34/34）, GMC being 1358IU/ml,25 times as was before the inoculation.The positive rate after re-inoculation was 100.00%（82/82）, in which the low, medium and high antibody positive rate accounted for 10.98%,79.27% and 9.75%,GMC being 1268IU/ml. The positive rate after re-inoculation was 100.00%（32/32）,while the medium and high level antibody positive rate both reached 100.00%,GMC being 2344IU/ml, 1.85 times as was before the re-inoculation.Conclusion Given the premise of high MV vaccination rate,the level of immune success rate is the key to the prevention of measles. Inoculated children should receive re-inoculation at the age of 1.5 to 2 in order to further elevate their measles antibodies.