甲状腺功能减退症患者的血细胞计数及红细胞变化的临床意义

目的探讨血细胞计数及红细胞(RBC)在甲状腺功能减退症(以下简称甲减)患者中的影响变化及其临床意义。方法将2013年1~12月在笔者医院内分泌科经临床诊断为甲减的102例患者(甲减组)、同期健康检查者118例(对照组)进行血细胞分析,并将其主要参数进行比较。结果与对照组相比,甲减组的RBC、红细胞平均容积(MCV)、红细胞平均血红蛋白量(MCH)、红细胞平均血红蛋白浓度(MCHC)、血红蛋白(Hb)、血细胞比容(HCT)和红细胞分布宽度(RDW)差异均具有统计学意义(P<0.05),而白细胞(WBC)及血小板计数(PLT)差异无统计学意义(P>0.05)。结论甲状腺功能减退症患者除血细胞计数外,红细胞分析中主要参数均有变化,故临床诊断中发现红细胞变化异常合并甲减其余症状时,应进一步考虑是否存在甲减,同时临床治疗甲减应密切关注患者是否存在贫血,且给予抗贫血治疗。

Changes and Clinical Significance of Blood Count and Erythrocyte in Hypothyroidism Patients

Objective To study the changes and clinical significance of blood count and red blood cells (RBC) in patients with hypothyroidism. Methods Blood cells and its main parameters were compared between 102 patients diagnosed hypothyroidism from January to December in 2013 in Department of endocrinology of our hospital and 118 health inspectors during the same period. Results Compared with control group, RBC, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), hemoglobin (Hb), hematocrit (HCT) and red blood cell distribution width (RDW) of hypothyroidism group showed statistically significance (P<0.05), but there was no statistically significant difference in white blood cells (WBC) and platelet (PLT) (P>0.05). Conclusion In addition to the blood count, main parameters of red blood cell analysis have significant changes in hypothyroidism patients. Therefore, it should consider the existence of hypothyroidism when find abnormal change in red blood cells with other symptoms of hypothyroidism. Meanwhile, it should pay attention to the existence of anemia when treating hypothyroidism, and then give anti-anemia therapy.