| 急性脑血管病血浆内皮素含量变化的研究 |
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| 引用本文： | 罗文浩,黄本友. 急性脑血管病血浆内皮素含量变化的研究[J]. 华中科技大学学报(医学版), 1993, 0(Z2) |
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| 作者姓名： | 罗文浩 黄本友 |
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| 作者单位： | 襄樊市第一人民医院神经科，襄樊市第一人民医院神经科 襄樊 441000，襄樊 441000 |
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| 摘 要： | 采用放射免疫法测定 43例急性脑血管病(CVD)患者的血浆内皮素(ET)含量,发现在CVD 中,无论是脑梗塞组还是脑出血组,其急性期血浆 ET均明显高于对照组(P<0.01)。结果提示,在脑组织缺血缺氧状况下,ET 参与了机体的病理生理过程,并加重了脑组织的损伤。应用ET拮抗剂或 ET单克隆抗体中和体内 ET,可能成为治疗急性脑血管病的一种有效手段。
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| 关 键 词： | 内皮素 脑血管意外 脑梗塞 放射免疫 |
Changes of Endothelin Contents in Plasma of Acute Cerebral Vascular Diseases |
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| Luo Wenhao.Huang Youben. Changes of Endothelin Contents in Plasma of Acute Cerebral Vascular Diseases[J]. Journal of Huazhong University of Science and Technology(Health Sciences), 1993, 0(Z2) |
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| Authors: | Luo Wenhao.Huang Youben |
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| Affiliation: | Luo Wenhao.Huang Youben Department of Neurology,Xiangfan First People's Hospital,Xiangfan 441000 |
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| Abstract: | The endothelin contents in the plasma of forty-three cases of acute cerebral vascular diseases(CVD)and twenty-two cases of healthy persons were examined by means of radiommunoassay(RlA). The results indicated that in acute CVD,endothelin (ET)in plasma during the acute period was significantly higher than that in the control group(P<0. 01). This is true with cerebral infarction group and ceredral hemorrhage group. Our study sug gests that when brain tissues are short of oxygen, ET is involved in the pathological and physiological processes of body and aggravates damage to the brain tissues. This indicates that use of anti-ET agents or monoclonal antibody against ET to neutralize ET in the body could be a new approach for the treatment of acute CVD. |
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| Keywords: | endothelin cerebral infarction cerebral hemorrage radioimmunoassay |
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