Dental enamel pitting in tuberous sclerosis complex

We studied pitting of the dental enamel in cases of tuberous sclerosis complex (TSC), by staining defect sites. Many pits were found in the enamel of the TSC patients, especially on the labial surface of the incisors. Although the pathogenesis is unclear, pits of this type have been reported in TSC patients, but in the author's experience, have never been observed in cases of other diseases. On the basis of the results in this study and those previously published, we conclude that dental enamel pitting is a finding which suggests the diagnosis of TSC.