| 氟哌啶醇季铵盐衍生物对大鼠心室肌细胞L型钙电流的影响 |
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| 引用本文： | 黄展勤,石刚刚,郑锦鸿,高分飞,刘幸平.氟哌啶醇季铵盐衍生物对大鼠心室肌细胞L型钙电流的影响[J].中国药理学通报,2003,19(10):1129-1131. |
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| 作者姓名： | 黄展勤 石刚刚 郑锦鸿 高分飞 刘幸平 |
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| 作者单位： | 汕头大学医学院药物研究室,汕头,515031 |
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| 基金项目： | 国家自然科学基金资助,No 3 0 0 70 3 0 4，广东省科技计划项目资助 ,NoC3010 4，广东省自然科学基金重点项目资助,No 62 12 3 5 |
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| 摘 要： | 目的 研究氟哌啶醇季铵盐衍生物 (F2 )对大鼠心室肌细胞L型钙电流 (ICa)的影响。方法 采用酶急性分离的单个大鼠心室肌细胞 ,应用膜片钳全细胞记录技术 ,观察F2对ICa的影响。结果 F2 (1μmol·L-1)能抑制任何一膜电压下的ICa,使峰电流从 (1775 2± 36 0 4 ) pA减少至 (46 4±12 9 1) pA (n =8,P <0 0 1) ,并使ICa的电流 -电压曲线上移 ,但不改变ICa的电压依赖特征。结论 F2 对心肌细胞膜L型钙通道具有阻断作用
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| 关 键 词： | 氟哌啶醇 心肌细胞 钙通道 膜片钳 |
| 文章编号： | 1001-1978(2003)10-1129-03 |
| 修稿时间： | 2003年5月26日 |
Effect of quaternary ammonium salt derivative of haloperidol on L-type currents in rat ventricular myocytes |
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| HUANG Zhan Qin,SHI Gang Gang,ZHENG Jin Hong,GAO Fen Fei,LIU Xing Ping.Effect of quaternary ammonium salt derivative of haloperidol on L-type currents in rat ventricular myocytes[J].Chinese Pharmacological Bulletin,2003,19(10):1129-1131. |
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| Authors: | HUANG Zhan Qin SHI Gang Gang ZHENG Jin Hong GAO Fen Fei LIU Xing Ping |
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| Abstract: | AIM To study the effect of quaternary ammonium salt derivative of haloperidol (F 2) on L type calcium current ( I Ca ) in rat ventricular myocytes. METHODS Single ventricular cell of rat was obtained by enzymatic dissociation method. The currents were recorded with the whole cell configuration of the patch clamp technique. RESULTS F 2(1 μmol·L -1 ) decreased I Ca from ( 1 775 2 ±360 4) pA to (464±129 1) pA ( n =8, P< 0 01) and shifted the current voltage curve of I Ca upward, without affecting the voltage dependent properties of I Ca . CONCLUSION F 2 inhibited L type calcium current in rat ventricular myocytes. |
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| Keywords: | haloperidol myocyte L type calcium channels patch clamp technique |
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