| 高效液相色谱法测定米诺地尔搽剂中米诺地尔的含量 |
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| 引用本文： | 范玉峰,胡守莲.高效液相色谱法测定米诺地尔搽剂中米诺地尔的含量[J].中国医药指南,2010,8(8):42-43. |
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| 作者姓名： | 范玉峰 胡守莲 |
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| 作者单位： | 1. 河南省信阳职业技术学院附属医院,464000
2. 河南省信阳市食品药品检验所,464000 |
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| 摘 要： | 目的建立测定米诺地尔搽剂中米诺地尔含量的高效液相色谱(HPLC)检验方法。方法采用Nova-PaKC18色谱柱(150mm×4.6mm,5μm),流动相为甲醇-水(70∶30),流速为1.0mL/min,检测波长为285nm。结果米诺地尔在2.5～20mg/L浓度范围内含量与峰面积比呈现良好的线性关系(r=0.9999),平均回收率为99.5%,RSD为1.85%,最低检出浓度为0.5mg/L。结论本法能准确检测米诺地尔搽剂中米诺地尔的含量,因此可作为米诺地尔搽剂质量控制的有效测量方法。
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| 关 键 词： | 米诺地尔搽剂 高效液相色谱法 米诺地尔 |
The Content of Minoxidil about Minoxidil Liniment by High Performance Liquid Chromatography |
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| FAN Yu-feng,HU Shou-lian.The Content of Minoxidil about Minoxidil Liniment by High Performance Liquid Chromatography[J].Guide of China Medicine,2010,8(8):42-43. |
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| Authors: | FAN Yu-feng HU Shou-lian |
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| Institution: | 1 Affiliated Hospital of Xinyang Vocational and Technical College, Henan Xinyang 464000, China; 2 Food andDrug Inspection ofXinyang, Xinyang 464000, China) |
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| Abstract: | Objective A HPLC method was established for the determination of minoxidil in compound minoxidil liniment. Method A Nova- PaKC^18（150mm×4.6mm,5μm） column was used with the mobile phase of methanolowater（70 ： 30）at the detection wavelength of 285nm.The flow rate was 1.0mL/min. Result The linear range was 2.5-20mg/L（r=0.9999）.The average recovery and RSD were 99.5% and 1.85% respectively. The minimum detectable concentration was 0.5mg/L. Conclusion The method could be used for the determination of minoxidil in compound minoxidil liniment. Therefore it could be used as a effective quality control method for minoxidil liniment. |
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| Keywords: | Minoxidil liniment High performance liquid chromatography Minoxidil |
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