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Peripheral neuropathy in mutant diabetic mouse [C57BL/Ks (db/db)]
Authors:Anders A F Sima  David M Robertson
Institution:(1) Department of Pathology, Queen's University and Kingston General Hospital, K7L 3N6 Kingston, Ontario, Canada
Abstract:Summary A new animal model for the study of diabetic neuropathy is presented. The homozygote (db/db) of the mouse strain C57BL/Ks shows severe diabetes with longstanding hyperglycemia. Electrophysiological studies showed severely decreased motor nerve conduction velocity. Morphometric examination of sensory and motor nerves at different levels revealed absence of large myelinated fibers, with morphological features indicative of axonal atrophy.Supported by Grant No. MA-5857 from the Medical Research Council of Canada
Keywords:Diabetic neuropathy  Motor nerve conduction velocity  Morphometry  Morphology
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