氩氦刀联合介入治疗复发、难治性非小细胞肺癌的临床分析

目的探讨复治性非小细胞肺癌的治疗方法。方法对62例放化疗后未控制病情的非小细胞肺癌患者进行氩氦刀冷冻联合介入治疗,测定治疗前后血清肿瘤标志物(NSE、CEA、CY21-1)含量及细胞核仁组成区相关蛋白(Ag-NORs)值(I.S%、I.O.D%),观察其疗效及1年生存率。结果治疗后血清标志物测定明显降低,(P<0.01);I.S%、I.O.D%值明显降低,(P<0.05);有效率79.0%(49/62),1年生存率80.6%(50/62)。结论氩氦刀联合介入对复治性非小细胞肺癌仍然有效。是解决复发难治性非小细胞肺癌的新途径。

Clinical analysis of the therapy for recurrent and intractable non-small cell lung cancer with combination of cryoablation and intervention

Objective To explore the re-treatment approach for nonsmall-cell lung cancer(NSCLC)in clinic with therapeutic alliance of cryotherapy and interventional chemotherapy. Methods Sixty two patients with uncontrolled NSCLC after common radiotherapy and(or)chemotherapy were re-treated with therapeutic alliance of cryotherapy and interventional chemotherapy, and their serum tumor markers of NSE, CEA, CY21-1 and the value(I.S%,I.O.D%)of correlative protein in nucleolus region-Ag-NORs were tested before and after the re-treatment. Meanwhile, patients' one year survival and therapeutic effect to NSCLC were recorded during the follow up. Results After the re-treatment, distinguished decline of the serum tumor markers was observed(P < 0.01=and values of Ag-NORs(I.S% and I.O.D%)were obviously lowered down. The therapeutic effect and one year survival were 79.03%(49/62)and 80.63%(50/62)respectively. Conclusion Therapeutic alliance of cryotherapy and interventional chemotherapy is a kind of effective re-treatment for NSCLC and also as a new approach for the refractory NSCLC.