| 西拉普利对高血压病人胰岛素抗药性的影响 |
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| 引用本文： | 金翠燕,王宪衍,钱珠,邱慧丽,王孝铭,戚文航. 西拉普利对高血压病人胰岛素抗药性的影响[J]. 中国新药与临床杂志, 1997, 0(4) |
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| 作者姓名： | 金翠燕 王宪衍 钱珠 邱慧丽 王孝铭 戚文航 |
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| 作者单位： | 上海市高血压研究所，上海第二医科大学附属瑞金医院 |
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| 摘 要： | 目的：为探索西拉普利治疗高血压病疗效及其对胰岛素抗药性的影响。方法：采用随机对照法对原发性高血压３０例（男性１６例，女性１４例，年龄４８±ｓ１０ａ），用西拉普利２．５～５．０ｍｇ／ｄ，疗程４ｗｋ。对照组为２０例（男性１１例，女性９例；年龄５２±７ａ），用氢氯噻嗪２５～５０ｍｇ／ｄ，疗程４ｗｋ。结果：西拉普利和氢氯噻嗪都有明显降压作用，但只有西拉普利有改善胰岛素抗药性的效应。结论：西拉普利治疗高血压病人有改善胰岛素抗药性的作用，对糖代谢起良好的影响。
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| 关 键 词： | 西拉普利；高血压；胰岛素抗药性；氢氯噻嗪 |
Effect of cilazapril on insulin resistance in patients with essential hypertension |
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| JIN Cui-Yan,WANG Xian-Yan,QIAN Zhu,QIU Hui-Li,WANG Xiao-Ming,QI Wen-Hang. Effect of cilazapril on insulin resistance in patients with essential hypertension[J]. Chinese Journal of New Drugs and Clinical Remedies, 1997, 0(4) |
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| Authors: | JIN Cui-Yan WANG Xian-Yan QIAN Zhu QIU Hui-Li WANG Xiao-Ming QI Wen-Hang |
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| Abstract: | AIM: To study the effect of cilazapril on insulin resistance(IR) in patients with essential hypertension. METHODS: In a randomized and controlled design, cilazapril was used in a dosage of 2.5-5.0 mg once daily in 30 patients (M 16, F 14; age 48±s 10 a) with essential hypertension for 4 wk and was compared with that of hydrochlorothiazide (25-50 mg/d, for 4 wk) in 20 patients (M 11, F 9; age 52±7 a). RESULTS: Cilazapril and hydrochlorothiazide both showed decreases in blood pressure, but only cilazapril improved the IR. CONCLUSION: Cilazapril improves IR in essential hypertension and is beneficial on glucose metabolism. |
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| Keywords: | cilazapril hypertension insulin resistance hydrochlorothiazide |
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