女性生理周期心电图T波改变的特点及临床意义

目的：研究女性生理周期中心电图T波改变的特点，并探讨其与雌激素水平的相关性。方法选取2014年3月至2015年5月间于我院进行常规体检中出现心电图T波改变的健康育龄女性100例，分别行常规12导联心电图检查，测定血清中雌二醇水平，并进行相关性分析。结果育龄女性生理周期(月经期、子宫内膜增生期和子宫内膜分泌期)心电图T波改变的主要特征为低平或倒置，而排卵期心电图T波正常(变成直立)；排卵期雌二醇水平为(314.6±95.8) pmol/L，明显低于月经期的(336.4±117.5) pmol/L、子宫内膜增生期的(438.4±135.4) pmol/L以及子宫内膜分泌期的(342.1±119.6) pmol/L，差异均具有统计学意义(P<0.05)；Spearman相关性分析表明，育龄女性生理周期雌激素水平变化与心电图T波改变具有显著正相关性(r=0.714，P<0.05)。结论健康育龄女性生理周期内心电图存在一定的T波改变，其可能与生理周期中雌激素水平变化相关。

Characteristics and clinical significance of changes of electrocardiogram T-wave in female physiologic cycle

Objective To study the change characteristics of electrocardiogram (ECG) in the female physiolog-ical cycles, and then to discusses its correlation with estrogen level. Methods A total of 100 cases of healthy women of childbearing age, who were found T-wave changes during the routine physical examination in our hospital from March 2014 to May 2015, were selected as the research subjects. Routine 12-lead electrocardiogram inspection was performed, the levels of serum estradiol (E2) levels was determined. The correlation analysis was carried out. Results The main characteristics of T wave changes of electrocardiogram in the female physiological cycles (menstrual period, endometrial hyperplasia and endometrial secretory phase) was low or inverted, while the ECG T-wave of ovulation phase was normal (into the upright). The level of estradiol during ovulation was (314.6 ± 95.8) pmol/L, which was significantly lower than (336.4 ± 117.5) pmol/L, (438.4 ± 135.4) pmol/L, (342.1 ± 342.1) pmol/L of menstrual period, endometrial hyperplasia and endometrial secretory phase, respectively (P<0.05). Spearman correlation analysis showed that there was a significant positive correlation between the change of estrogen level and ECG T-wave in women of childbearing age (r=0.714, P<0.05). Conclusion There were some physiological cycle T wave change in the healthy women during the physiological cycle, which may be related to the change of the estrogen level in the physiological cycle.