雌激素受体、孕激素受体、p53及Ki-67在子宫内膜癌组织中的表达及其与临床病理特征的关系

目的：观察雌激素受体(ER)、孕激素受体(PR)、p53及Ki-67在子宫内膜癌组织中的表达，并探讨其与临床病理特征的关系。方法选取2015年2月至2016年2月我院妇科收治的子宫内膜癌患者156例为观察组，选取同期正常子宫内膜组织70例为对照组，应用免疫组化分析法检测两组患者组织中ER、PR、p53及Ki-67的表达情况，并分析ER、PR、p53及Ki-67的表达与临床病理的关系。结果观察组患者的ER和PR表达阳性率分别为44.9%和41.0%，明显低于对照组的91.4%和94.3%，p53和Ki-67表达阳性率分别为86.5%和68.6%，明显高于对照组的0和0，差异均具有统计学意义(P<0.05)；Ⅲ~Ⅳ期患者的ER和PR表达阳性率分别为11.1%和18.5%，明显低于Ⅰ期和Ⅱ期患者，p53和Ki-67表达阳性率分别为100.0%和98.1%，明显高于I期和II期患者，差异均具有统计学意义(P<0.05)；组织分级G3级患者的ER和PR表达阳性率分别为17.6%和17.6%，明显低于G1级和G2级，p53和Ki-67表达阳性率分别为100.0%和82.4%，明显高于G1级和G2级，差异均具有统计学意义(P<0.05)；腺癌和非腺癌患者的ER、PR和p53表达阳性率比较差异均无统计学意义(P>0.05)，腺癌Ki-67表达阳性率为84.5%，明显高于非腺癌的42.4%，差异有统计学意义(P<0.05)。结论 ER、PR表达缺失和p53、Ki-67表达增高与子宫内膜癌有关，且与临床病理存在较大关系。

Expression of estrogen receptor,progesterone receptor,p53 and Ki-67 in endometrial carcinoma and their relationship with clinical pathological characteristics

Objective To observe the expression of estrogen receptor (ER), progesterone receptor (PR), p53 and Ki-67 in endometrial carcinoma, and to explore their relationship with clinical pathological characteristics. Methods A total of 156 patients with endometrial carcinoma, who admitted to Department of Gynecology of our hospital from Feb-ruary 2015 to February 2016, were selected as the observation group. At the same time, 70 patients with normal endome-trial tissue were chosen as the control group. The expressions of ER, PR, p53 and Ki-67 in two groups were detected by immunohistochemistry, and the relationship between the expressions of ER, PR, p53 and Ki-67 and clinical pathology were analyzed. Results The positive rates of ER and PR expression in the observation group were respectively 44.9%and 41.0%, which were significantly lower than 91.4% and 94.3% in the control group (P<0.05); the positive rates of p53 and Ki-67 expression were respectively 86.5%and 68.6%, which were significantly higher than 0 and 0 in the con-trol group (P<0.05). The positive rates of ER and PR expression in the period of Ⅲ~Ⅳ were respectively 11.1% and 18.5%, which were significantly lower than those in the period ofⅠandⅡ(P<0.05);the positive rates of p53 and ex-pression Ki-67 were respectively 100.0%and 98.1%, which were significantly higher than those in the period ofⅠandⅡ(P<0.05). The positive rates of ER and PR expression in G3 grade patients were respectively 17.6%and 17.6%, which were significantly lower than those in G1 and G2 grade patients (P<0.05);the positive rates of p53 and Ki-67 expression were respectively 100.0%and 82.4%, which were significantly higher than those in G1 and G2 grade patients (P<0.05). There was no significant difference in the positive rates of ER, PR and p53 expression between the patients with adeno-carcinoma and non-adenocarcinoma (P>0.05). The positive rate of Ki-67 expression in adenocarcinoma was 84.5%, which was significantly higher than 42.4%in non-adenocarcinoma (P<0.05). Conclusion The deletion expression of ER and PR and increased expression of Ki-67 and p53 are associated with endometrial cancer, and there is a significant relationship with clinical pathology.