复方丹参滴丸对糖尿病周围神经病变血液流变学及神经传导速度的影响

【目的】比较口服复方丹参滴丸与口服甲钴胺片对糖尿病周围神经病变患者的血液流变学及神经传导速度的影响。【方法】将70例糖尿病周围神经病变患者随机分为治疗组和对照组,每组各35例。2组均给予调控血糖、血脂、血压的基础治疗,治疗组患者给予口服复方丹参滴丸治疗,对照组给予口服甲钴胺片治疗,2组均连续治疗3个月。观察2组治疗前后对血液流变学及神经传导速度的影响。【结果】治疗后,2组患者的血液流变学各项指标及神经传导速度各项指标均较治疗前明显改善,差异均有统计学意义(P0.05),且治疗组对血液流变学各项指标的改善作用均明显优于对照组(P0.05),而对神经传导速度各项指标的改善作用则与对照组相同(P0.05)。【结论】口服复方丹参滴丸对糖尿病周围神经病变神经传导速度的影响与口服甲钴胺片相同,但对血液流变学指标的改善作用则优于口服甲钴胺片,可有效改善患者的肢体血流及神经传导速度。

Effects of Compound Danshen Dripping Pills on Hemorheology and Nerve Conduction Velocity of Diabetic Peripheral Neuropathy Patients

Objective To compare the effects of oral use of Compound Danshen Dripping Pills and Mecobalamin Tablets on hemorheology and nerve conduction velocity of diabetic peripheral neuropathy patients. Methods A total of 70 diabetic peripheral neuropathy patients were randomized into treatment group and control group, 35 cases in each group. Both groups were given fundamental treatment for controlling blood glucose, blood lipids and blood pressure, and additionally the treatment group was treated with Compound Danshen Dripping Pills orally and the control group was treated with Mecobalamin Tablets orally. The treatment for the two groups lasted 3 continuous months. The changes of hemorheology and nerve conduction velocity of the two groups were observed before and after treatment. Results After treatment, indexes of hemorheology and nerve conduction velocity of the two groups were much improved(P<0.05 compared with those before treatment). The improvement of hemorheology indexes in the treatment group was superior to that in the control group (P < 0.05), but the difference of improvement of nerve conduction velocity was insignificant between the two groups (P > 0.05). Conclusion The effects of oral use of Compound Danshen Dripping Pills on the nerve conduction velocity of diabetic peripheral neuropathy patients are similar to those of Mecobalamin Tablets, but the pills have better effects on improving hemorheology than the tablets. The results indicated that Compound Danshen Dripping Pills are effective on improving blood flow and nerve conduction velocity of the limbs of the patients.