| MCP-1在大鼠视网膜缺血再灌注损伤中的表达及意义研究 |
| |
| 引用本文： | 游志鹏,姜德咏,李国栋,赵宏伟. MCP-1在大鼠视网膜缺血再灌注损伤中的表达及意义研究[J]. 中国现代医学杂志, 2003, 13(23): 26-28,32 |
| |
| 作者姓名： | 游志鹏 姜德咏 李国栋 赵宏伟 |
| |
| 作者单位： | 中南大学湘雅二医院眼科,长沙,410011 |
| |
| 摘 要： | 目的了解MCP-1在大鼠视网膜缺血再灌注损伤中的表达及意义。方法建立大鼠视网膜缺血再灌注模型，以SABC法检测MCP-1在视网膜中的表达，统计学分析。结果 MCP-1在视网膜缺血再灌注6h开始表达，第24小时达到最高峰，48h开始表达减弱。结论MCP-1在视网膜缺血再灌注损伤中起重要作用。
|
| 关 键 词： | MCP-1 视网膜 缺血再灌注损伤 |
Research of MCP-1 expression in rat''''s retina injured by ischemia-reperfusion |
| |
| YOU Zhi-peng,JIANG De-yong,LI Guo-dong and ZHAO Hong-wei. Research of MCP-1 expression in rat''''s retina injured by ischemia-reperfusion[J]. China Journal of Modern Medicine, 2003, 13(23): 26-28,32 |
| |
| Authors: | YOU Zhi-peng JIANG De-yong LI Guo-dong ZHAO Hong-wei |
| |
| Affiliation: | YOU Zhi-peng,JIANG De-yong,LI Guo-dong and ZHAO Hong-wei Department of Ophthalmology,Second Xiangya Hospital,Central South University,Changsha 410011 |
| |
| Abstract: | Objective:The retina ischemia-reperfusion injury is caused by many factors. A lot of cell factors take part in it. Many researches suggest MCP-1 has special effect on leukocyte and lymphocyte.The research try to study the effect of MCP-1 in rat's retina ischemia-reperfusion injury.Methods:To employ the rat's retina ischemia-reperfusion model and use SABC method to test the expression of MCP-1 on retina.Results:There was no MCP-1 expressed in retina after ischemia-reperfusion injury for one hour. MCP-1 began to express in retina after ischemia-reperfusion injury for six hours, and expressed at most after ischemia-reperfusion injury for 24 hours. Then it began to decrease in 48 hours after ischemia-reperfusion injury, but it still expressed in retina in seventy-two hours after ischemia-reperfusion injury.Conclusions:MCP-1 plays an important role in rat's retina ischemia-reperfusion injury. |
| |
| Keywords: | MCP-1 ischemia-reperfusion injury retina |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
