传染性非典型肺炎急性期患者血清特种蛋白的检测及意义

目的 探讨传染性非典型肺炎又称严重急性呼吸综合征(SARS)患者急性期血清特种蛋白的变化规律及其临床意义。方法 SARS急性期组:本院临床诊断为SARS,发病后5 d内患者42例。正常对照组:体检健康成年人30名。采用速率散射比浊法检测血清中免疫球蛋白G(IgG)、免疫球蛋白A(IgA)、免疫球蛋白M(IgM)、补体C3(C3)、补体C4(C4)、C反应蛋白(CRP)、al酸性糖蛋白(al-AG)、al抗胰蛋白酶(al-AT)、转铁蛋白(TRF)、铜蓝蛋白(CER)的浓度。结果 与正常对照组相比,急性时相反应蛋白中CRP、al-AG、al-AT明显升高(P<0.01);TRF明显降低(P<0.01);CER略有降低,但无统计学意义(P>0.05);补体中C3水平降低(P<0.01);C4水平升高(P<0.01)。免疫球蛋白中IgG、IgA、IgM皆无显著性差异(P>0.05)。结论 SARS急性期患者血清中特种蛋白的浓度变化有一定的规律。在SARS急性期联合检测CRP、al-AG、TRF,对急性期SARS患者炎症的严重程度的判断有一定的参考价值。

Detection of specific proteins in serum of acute stage patients with SARS and its clinical application

Objective To observe the changes of specific proteins in serum of acute stage patients with SARS and its clinical application. Methods The acute stage patients with SARS group included 42 cases who had clinical symptoms less than five days. In normal group: 30 healthy adults were as controls. Tests for specific proteins were immunoglobin G ( IgG ) , immunoglobin A ( IgA) , immunoglobin M ( IgM) , complement C3( C3),complement C4(C4),C-reaction protein (CRP), al acid glycoprotein( a1-AG) , a1 antitrypsin(a1-AT) ,transferrin(TRF), ceruloplasmin( CER) in sera by Ratenephelometer. Results The level of CRP, a1-AG, a1-AT in sera of patients with SARS were higher than that in control group ( P < 0. 01) . TRF in patient group was lower than that in control group (P < 0. 01). C3 in patient group was lower. C4 was higher (P<0. 01). CER,.IgG, IgA and IgM had no significant differences between the two groups ( P > 0. 05). Conclusion It suggested that specific proteins in serum of acute stage patients with SARS change in a particular way. There were some help for the diagnosis of the phlogistic degree of acute stage patients with SARS by detecting CRP, a1-AG and TRF simultaneously.