非酒精性脂肪肝患者C反应蛋白和胰岛素抵抗观察

目的:观察非酒精性脂肪肝(NAFLD)患者C反应蛋白(CRP)及胰岛素抵抗(IR)情况。方法:对64例脂肪肝患者根据口服糖耐量试验(OGTT)结果分为脂肪肝糖耐量正常组(NGT)和异常组(IGT),同时选择20例正常人为对照(NC),检测空腹血糖(FPG)、空腹胰岛素水平(FINS)及C反应蛋白水平。采用稳态模式评估法(HO-MA)计算胰岛素抵抗指数(HOMA-IR)。结果:NGT和IGT之间及其与NC之间HOMA-IR和CRP比较差异均有统计学意义(P<0.05)。NAFLD患者随着OGTT异常程度的增加,CRP及HOMA-IR有逐渐增高的趋势,二者均与NAFLD呈正相关关系(r=0.217,P<0.05;r=0.263,P<0.02)。结论:NAFLD可能成为预测炎症状态和IR的指标。改善肝脏脂肪代谢,减轻炎症状态可能有利于减轻IR。

Relationship between insulin resistance and C-reactive protein in patients with nonalcoholic fatty liver disease

Aim: To investigate the relationship between insulin resistance (IR) and C-reactive protein(CRP) in patients with nonalcoholic fatty liver disease(NAFLD).Methods: Standard oral glucose tolerance test (OGTT) was performed in 64 patients with NAFLD and the patients were allocated into normal glucose tolerance group and abnormal glucose tolerance group.Twenhy healthy volunteers were chosen as normal control.Fasting insulin levels (FINS) and glucose and CRP were measured in 64 patients with NAFLD. The index of IR was calculated according to the HOMA method.Results: HOMA-IR and CRP between the 3 groups had significant differences(P<0.05).HOMA-IR and CRP increased with the increase of abnomal extent of glucose tolerance.Both of them were positively correlated with NAFLD(r=0.217,P<0.05;r=0.263,P<0.02) .Conclusion: NAFLD can be an important predictor for screening inflammation and IR. Amelioration of lipometabolism in liver and mitigation of inflammation may help to reduce the extent of IR.