5Hz和20Hz磁场刺激对大鼠脑缺血影响的比较研究

目的 观察5Hz和20Hz磁场对脑缺血损害的影响。方法 采用左侧颈总动脉阻断致大鼠急性脑缺血，缺血后给予5Hz和20Hz的磁场刺激3h或5h。观察脑细胞的缺血性病理变化。结果 锥体细胞和星形胶质细胞表现出不同的缺血性病理变化；对锥体细胞的缺血性损害5Hz组轻于对照组和20Hz组，而对星形胶质细胞则表现为5Hz组的缺血性损害程度重于对照组和20Hz组；20Hz组的缺血性损害程度与对照组相似。结论 不同频率的磁场对大鼠脑急性缺血性损害有不同的影响，磁场的频率效应可能与磁场作用机制及细胞的不同特性有关。

Comparison of Effects of 5 and 20 Hz Magnetic Field on Cerebral Ischemia in Rats

Objective To compare the effects of 5 Hz and 20 Hz magnetic field on cerebral ishemia in rats. Method After cerebral ischemia was produced by ligation of the left general carotid artery,rats were stimulated by magnetic fields of 5 Hz and 20 Hz respectively and pathological changes in neurocytes were observed. Result (1) Different pathological changes were observed in different cells;(2)The extent of damage of pyramidal cells was milder in 5 Hz magnetic field groups than those in the control group ,and the effect was not remarkable in the 20 Hz group;(3)The effect on astroglia was worse in 5 Hz group than that in control and 20 Hz group. Conclusion Magnetic field stimulation influences cerebral ischemic reaction with frequency dependency.