| 阿替普酶对急性ST段抬高型心肌梗死窦性心率震荡的影响 |
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| 引用本文： | 王楚林,吴强,林宇鹏,徐名伟,游琼.阿替普酶对急性ST段抬高型心肌梗死窦性心率震荡的影响[J].心血管康复医学杂志,2013(6):595-598. |
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| 作者姓名： | 王楚林 吴强 林宇鹏 徐名伟 游琼 |
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| 作者单位： | [1]广东省揭阳市人民医院心血管一科,广东揭阳522000 [2]广东医学院附属医院心血管内科,广东揭阳522000 |
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| 摘 要： | 目的：探讨阿替普酶治疗对急性ST段抬高型心肌梗死（STEMI）的窦性心率震荡的影响。方法：68例STEMI患者按数字表法被随机均分为尿激酶组（34例）和阿替普酶组（34例）。检测24h动态心电图，分析计算窦性心率震荡震荡初始（T0）、震荡斜率（TS）]。统计临床溶栓再通率及再通时间、胸痛症状缓解率以及终点事件。结果：与尿激酶组比较，阿替普酶组再通率（52．9％比73．5％）、胸痛症状缓解率（55．9％比82．4％）及TS（5．50±2．11）ms／RR比（8．69±3．82）ms／RR]均显著升高，T0（2．34±0．28）％比（0．75±0．04）％]明显降低，P〈0．05或〈0．01；与尿激酶溶栓再通亚组比较，阿替普酶溶栓再通亚组溶栓再通时间（183．1±62．9）min比（120．6±54．8）min]显著减少、T0（1.16±0．13）％比（0．32±0．06）％]显著降低，TS（8．42±2．93）ms／RR比（12．13±4．65）ms／RR]显著升高，P〈0．05或〈0．01。结论：阿替普酶治疗急性ST段抬高型心肌梗死的临床疗效较尿激酶明显，能有效改善窦性心率震荡。
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| 关 键 词： | 心肌梗塞 组织型纤溶酶原激活物 血栓溶解疗法 |
Influence of alteplase on sinus heart rate turbulence in acute ST - segment elevation myocardial infarction |
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| WANG Chu-lin,WU Qiang,LIN Yu-peng,XU Ming-wei,YOU Qiong.Influence of alteplase on sinus heart rate turbulence in acute ST - segment elevation myocardial infarction[J].Chinese Journal of Cardiovascular Rehabilitation Medicine,2013(6):595-598. |
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| Authors: | WANG Chu-lin WU Qiang LIN Yu-peng XU Ming-wei YOU Qiong |
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| Institution: | (Department of Cardiology, People＇s Hospi- tal of Jieyang City, Jieyang, Guangdong, 522000, China) |
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| Abstract: | Objective： To explore influence of alteplase on sinus heart rate turbulence （HRT） in patients with acute ST-segment elevation myocardial infarction （STEMI） and its therapeutic effects. Methods： A total of 68 STEMI patients were randomly divided into urokinase group （n = 34） and alteplase group （n = 34） according to number table. The 24h ambulatory electrocardiography was measured, and then sinus HRT turbulence onset （TO）and turbulence slope （TS）] was calculated and analyzed; clinical thrombolysis recanalization rate etc. was statistically counted in all patients. Results： Compared with urokinase group, there were significant increase in reeanalization rate （52.9 % vs： 73.5%）, remission rate of chest pain （55.9% vs. 82.4%） and TS （5.50 ±2.11） ms/RR vs. （8. 69 ±3. 82） ms/ RR], and significant decrease in TO （2.34 ±0.28） % vs. （0.75 ±0.04） %] in alteplase group, P〈0.05 or 〈0.01 ; compared with recanaUzation subgroup of urokinase, there were significant decrease in thrombolysis recanalization time （183.1 ±62.9） min vs. （120.6 ±54. 8） mini and T0 （1.16 ±0.13） % vs. （0.32 ±0.06） %], and significant increase in TS （8.42 ±2.93） ms/RR vs. （12.13 ±4. 65） ms/RR] in recanalization subgroup of alteplase group, P 〈0. 05 or 〈0. 01. Concision： Alteplase possesses significant clinical therapeutic effect for acute ST-segment elevation myocardial infarction and can effectively improve sinus heart rate turbulence. |
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| Keywords: | Myocardial infarction Tissue plasminogen activator Thrombolytic therapy |
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