皮肤癣菌病患者表皮LC观察

本文应用ATPase组化方法对30例皮肤癣菌病患者皮损表皮及70例对照者相应部位表皮作了LC观察,并对其中3例患者及1例对照者表皮LC作了TEM观察.结果发现患者LC形态改变,数量减少或消失及细胞超微结构受损.并发现上述改变程度与病程、病型有关.本文首次提出LC与皮肤癣菌病的免疫病理改变有密切关系,可能皮肤癣菌的入侵使LC受损,从而干扰了T淋巴细胞诱导的机体对病原体的清除功能.本文还讨论了两种方法的注意点.

OBSERVATION ON LC IN INVOLVED EPIDERMIS OF PATIENTS WITH DERMATOMYCOSES BY TEM AND ATPase STAINING

The investigation of LC is involved epidermis of 30 patients with dermatomyccsis and in corresponding sites of 70 controls wre mzde by using ATPase staining,and among them 3 patients and 1 control were also eaamincd by usingTEM.The results showed that the number of the LC of the patients were diminished or disappeared,and the ultrastructura were damaged as observed respectively by ATPase staining and TEM.The degree of damage related with the duration and the type of the disease.The close correlation of LC with the immunopathologic changes in dermatomycosis is for the first time proposcd.The invading of dermatophytes impairs the LC,it is possible that the eliminating functioa of the organism to pathogens induced by T cell is interfemd.