| 盐酸沙格雷酯的合成 |
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| 引用本文： | 王生,陈国华,张海军. 盐酸沙格雷酯的合成[J]. 中国医药工业杂志, 2008, 39(12) |
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| 作者姓名： | 王生 陈国华 张海军 |
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| 作者单位： | 中国药科大学药物化学教研室,江苏南京,210009 |
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| 摘 要： | 水杨醛经苄基保护﹑还原﹑氯代﹑Arbuzov反应﹑Wittig-Horner反应﹑催化氢化得到2-[2-(3-甲氧基苯基)乙基]苯酚,再与环氧氯丙烷反应成醚﹑胺化开环﹑酯化﹑与盐酸成盐得到盐酸沙格雷酯,总收率约为46%。
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| 关 键 词： | 盐酸沙格雷酯 2-[2-(3-甲氧基苯基)乙基]苯酚 抗血栓药 合成 |
Synthesis of Sarpogrelate Hydrochloride |
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| WANG Sheng,CHEN Guo-hua,ZHANG Hai-jun. Synthesis of Sarpogrelate Hydrochloride[J]. , 2008, 39(12) |
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| Authors: | WANG Sheng CHEN Guo-hua ZHANG Hai-jun |
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| Abstract: | Sarpogrelate hydrochloride was synthesized with about 46% overall yield from salicylicaldehyde via benzyl protection,reduction,chlorination,Arbuzov reaction,Wittig-Horner reaction,catalytic hydrogenation to give 2-2-(3-methoxyphenyl)ethyl phenol,which was subjected to react with epichlorohydrin,amination,esterifi cation and salt formation. |
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| Keywords: | sarpogrelate hydrochloride 2-2-(3-methoxyphenyl)ethyl phenol antithrombotic drug synthesis |
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