| 用多波长面积积分法对氮酮促进酮康唑透皮吸收的研究 |
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| 引用本文： | 王晓波,岳平,邢山闽,朱桂芝,兰学山,周改先. 用多波长面积积分法对氮酮促进酮康唑透皮吸收的研究[J]. 沈阳药科大学学报, 1991, 0(1) |
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| 作者姓名： | 王晓波 岳平 邢山闽 朱桂芝 兰学山 周改先 |
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| 作者单位： | 中国人民解放军第二一○医院临床药理室(王晓波，岳平，邢山闽，朱桂芝，兰学山)，中国人民解放军第二一○医院临床药理室(周改先) |
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| 摘 要： | 本文采用简单小室装置,多波长面积积分紫外分光光度法研究了氮酮(Azone,A)对酮康唑(Ketoconazole,KCZ)的透皮吸收作用,证明24h时,3%A可使KCZ的透皮吸收率增加2.85倍。同时用抛物线拟合法建立了不同时间下A浓度对KCZ透皮吸收率的数学模型,用此模型准确求得了A对KCZ透皮吸收的最佳用量为2.56%±0.335%.此研究对制订外用KCZ制剂处方中A的最佳用量奠定了基础。
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| 关 键 词： | 多波长面积积分 紫外分光光度法 氮酮 酮康唑 透皮吸收 抛物线拟合 |
STUDY AZONE ON TRANSDERMAL ABSOMPTION OF KETOCONAZOLE BY MULTI-WAVELENGTHS AREA INTEGAL METHOD |
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| Wang Xiaobo Yue Ping Xing Shanmin Zhu Guizhi Lan Xueshan Zhou Gaixian. STUDY AZONE ON TRANSDERMAL ABSOMPTION OF KETOCONAZOLE BY MULTI-WAVELENGTHS AREA INTEGAL METHOD[J]. Journal of Shenyang Pharmaceutical University, 1991, 0(1) |
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| Authors: | Wang Xiaobo Yue Ping Xing Shanmin Zhu Guizhi Lan Xueshan Zhou Gaixian |
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| Affiliation: | Wang Xiaobo Yue Ping Xing Shanmin Zhu Guizhi Lan Xueshan Zhou Gaixian Department of Clinical Pharmacology,210 Hospital of the Chinese People's Liberation Army,Dalian |
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| Abstract: | A simple cell was used as experimental apparatus. The Ketoconazole concentration was determined by multi-wavelength areal integral UV-spectrophotometry. The methematic model of ketoconazole transdermal absorption rate at different azone concentrations was evaluated by the parabolic curve fitting method. The best concentration of azone for transdermal absorption of ketoconazole was 2.56±0.335%. At 3% azone, the transdermal absorption rate of ketoconazole in 24 hours increased by about 2.85 time. |
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| Keywords: | Multi-wavelengths area integal Ultra-violet-spectrophotometry Azone Ketoconazole Transdermal absorption Parabolic curve fitting |
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