|
|||||
|
|
t(8;21) prior to acute leukemia |
|
| Authors: | Roland Berger Josette Hillion Daniel Janvier Zhu Chen Annette Bussel |
| Affiliation: | a INSERM U 301 IGM, Paris, France. b CNRS SDI No. 15954 I, IGM, Paris, France. c Secteur d'Hémobiologie-Transfusion Paris-Est, Hôpital Lariboisière, Paris, France. d Laboratory of Molecular Biology, Shanghai Second Medical University, Shanghai, China e Centre d'Hémobiologie et Transfusion, Hôpital Saint Louis, Paris, France. |
| Abstract: | A t(8;21)(q22;q22) without blood and bone marrow invasion by immature myeloid precursor cells occurred in a patient previously treated for polycythemia vera. The presence of a molecular rearrangement confirmed that the chromosomal abnormality was identical to that observed in acute leukemia with t(8;21). This case shows that the translocation, t(8;21), may occur in myelodysplasia and suggests that it can precede the appearance of overt leukemia. |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ | |