Effect of cimetidine on the pharmacokinetics of theophylline |
| |
Authors: | O Shaheen N A Sliman W A Al-Turk |
| |
Affiliation: | Faculty of Medicine, University of Jordan, Amman. |
| |
Abstract: | 1. The effect of the therapeutic doses of cimetidine (400 mg/twice daily) on theophylline metabolism in Jordanian volunteers was studied. 2. The administration of the above therapeutic cimetidine dose did not alter theophylline clearance and elimination half-life. 3. Cimetidine administration also failed to alter the elimination of theophylline metabolites in urine. |
| |
Keywords: | |
|