Bcl-2在盐酸米诺环素软膏联合牙周塞治剂治疗兔牙周病中的表达

目的观察Bcl-2在牙周病的发生发展的变化中的敏感程度，观察牙周塞治剂是否能加强盐酸米诺环素软膏治疗牙周病的效果。方法选40只日本大耳白兔，其中4只作为对照组，其余36只日本大耳白兔随机分为牙周炎未治疗组（牙周炎组12只）、牙周炎应用盐酸米诺环素软膏组（派丽奥组12只），牙周炎应用盐酸米诺环素软膏和牙周塞治剂组（塞治剂12只）。检测Bcl-2在牙龈组织中的表达及各组牙周病的指标比较。结果应用盐酸米诺环素软膏合用牙周塞治剂后，牙周袋深度（PD）、龈沟出血指数（SBI）明显降低（P〈0．05），Bcl-2在牙龈组织中的表达明显升高（P〈0．05）。结论牙周塞治剂能明显提高派丽奥治疗兔牙周炎的效果，Bcl-2是牙周炎的敏感指标。

The Various Contents of Bcl-2 in Minocycline Hydrochloride Combine with Periodontal Pack to Heal Periodontal Disease

objective To observe the sensitivity of Bcl-2 in the periodontal disease and to observe if the periodontal pack can improve the healing effect of minocycline hydrochloride.Methods There are forty rabbits.Four rabbits were ready to set up as control group.Thirty-six rabbits were randomly assigned into 3 groups(n=12 each),no treated periodontal disease group,minocycline hydrochloride to heal periodontal disease,minocycline hydrochloride combine with periodontal pack to heal periodontal disease.All rabbits wer...