In vitro activities of tritrpticin alone and in combination with other antimicrobial agents against Pseudomonas aeruginosa |
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| Authors: | Cirioni Oscar Giacometti Andrea Silvestri Carmela Della Vittoria Agnese Licci Alberto Riva Alessandra Scalise Giorgio |
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| Affiliation: | Clinica Malattie Infettive, Ospedali Riuniti Ancona, via Conca 71, I-60020 Ancona, Italy. |
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| Abstract: | The in vitro activity of the cathelicidin tritrpticin was investigated against multidrug-resistant Pseudomonas aeruginosa. The isolates were susceptible to the peptide at concentrations of 0.50 to 8 mg/liter. Tritrpticin completely inhibits lipopolysaccharide procoagulant activity at a 10 microM concentration. Fractionary inhibitory concentration indexes (0.385, 0.312, and 0.458) demonstrated synergy between the peptide and beta-lactams. |
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