| ERCC1基因多态性与非小细胞肺癌预后的相关性 |
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| 引用本文： | 王伟力,潘宏,钟文,郭根燕,周春宇,张国云. ERCC1基因多态性与非小细胞肺癌预后的相关性[J]. 中国实验诊断学, 2013, 0(5): 854-857 |
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| 作者姓名： | 王伟力 潘宏 钟文 郭根燕 周春宇 张国云 |
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| 作者单位： | 中国医科大学附属第四医院肿瘤放射治疗科,辽宁沈阳110032 |
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| 摘 要： | 目的研究证实ERCC1基因多态性与非小细胞肺癌预后的相关性。方法对119例接受胸部根治性放疗的非小细胞肺癌患者进行ERCC1基因分型,统计分析其与患者放疗后总生存的相关性。结果 Codon118基因型频率分别为TT45.4%（54/119）、TC39.5%（47/119）、CC15.1%（18/119）。C8092A基因型频率分别为CC48.7%（58/119）、CA39.5%（47/119）、AA11.8%（14/119）。Condon118的TT基因型与CT/CC基因型患者总生存的差异具有统计学意义（59.3%vs75.4%,P=0.034）。而C8092A的CC基因型与CA/AA基因型患者总生存的差异无统计学意义（62.1%vs78.7%,P=0.052）。结论 ERCC1Codon118多态性可能与非小细胞肺癌患者预后相关联。
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| 关 键 词： | 基因多态性 ERCC1基因 非小细胞肺癌 放射治疗 预后 |
Relationships between polymorphisms of ERCC1 and efficacy of non-small cell lung cancer receiving radiation therapy |
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| Affiliation: | WANG Wei-li ,PAN Hong ,ZHONG Wen ,et al. (Departznent of Radiation Oncology ,the Fourth Affiliated Hospital, China Medical University, Shenyang 110032, China) |
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| Abstract: | Objective To explore the relationships between polymorphisms of ERCC1 and the efficacy of radiation therapy in non-small cell lung cancer patients. Methods 119 non-small cell lung cancer patients treated with definitive radiation therapy were enrolled in this study. The ERCC1 genotypes were determined by RFLP-PCR method. Survival analysis was performed to evaluate the relationship between OS and ERCC1 genotypes. Results The frequency of Codon118 was TT45.4% （54/119） ,TC39. 5% （47/119） ,CC15. 1% （18/119）,and the frequency of C8092A was CC48.70%（58/119） ,CA39.5%（47/119） ,AA11. 8% （14/119）. The survival difference between TT genotype and CT/CC genotype of Codonll8 was statistically significant but not C8092A. Conclusion The polymorphisms of ERCC1 Codonll8 may be significantly associated with radiation therapy efficacy. |
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| Keywords: | Polymorphism ERCC1 Non-small cell lung cancer Radiotherapy Prognosis |
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