氨基酸末端脑钠素前体与心房颤动的相关性研究

目的探讨血清中氨基酸末端脑钠素前体（NT—pro BNP）水平与心房颤动（房颤）之间的关系。方法病例组心血管病患者136例，心功能I～Ⅱ级（NYHA分级），其中房颤患者90例，窦性心律患者46例；健康对照组30例。应用竞争性酶联免疫分析（ELISA）定量测定血清中NT—pro BNP水平，并进行统计学分析。结果房颤患者血清NT—pro BNP水平显著高于窦性心律患者和对照组（P〈0．01），窦性心律患者与对照组之间血清NT—pro BNP水平差异无统计学意义（P〉0．05）；房颤、年龄、右心房内径是血清NT—pro BNP水平升高的独立预测因素。结论房颤患者血清NT—pro BNP水平明显升高，监测血清NT—pro BNP水平的变化有助于房颤患者心功能的评价。

Clinical study of relationship between NT-proBNP and atrial fibrillation

Objective To investigate the relationship between serum N-terminal fragment pro-brain natriuretic peptide( NT-proBNP) levels and atrial fibrillation (AF). Methods Serum NT-proBNP levels were measured by ELISA in 136 subjects(90 with AF, 46 in sinus rhythm). Subjects were excluded if they had a history of myocardial infarction, cardiomyopathy, rheumatic heart disease, or hyperthyroidism that proceded the onset of AF. Control subjects (30) were obtained from a healthy outpatient primary care population. Potential determinants of serum NT-proBNP levels were identified by univariate and multivariate. Results Individuals with AF had higher serum NT-proBNP levels than those with sinus rhythm and control subjects(P< 0. 01, respectively ). In individuals with sinus rhythm and control subjects did not show difference at serum NT-proBNP levels ( P > 0. 05). The final regression model showed that presence of AF, older age and larger right atrial diameter were independent predictors of higher serum NT-proBNP values. Conclusions Presence of AF in patients is associated with elevated serum NT-proBNP levels. Examining the change of serum NT-proBNP levels has evaluation value in cardiac function of patients with AF.