南五味子软胶囊的一般药理作用研究

目的：观察南五味子软胶囊口服给药对小鼠精神神经系统和麻醉犬心血管系统及呼吸系统的影响，探讨其用药安全性。方法：以不同剂量南五味子软胶囊给予小鼠（100，200，400 mg·kg^-1）ig给药，观察给药后小鼠的一般行为表现、自主活动、协调运动能力和协同戊巴比妥钠作用，考察对其精神神经系统的影响；以不同剂量南五味子软胶囊（50，100，200 mg·kg^-1）对麻醉犬十二指肠给药，观察给药前后相关指标的变化，考察其对麻醉犬心血管系统及呼吸系统的影响。结果：南五味子软胶囊对小鼠一般行为表现无明显影响，在转棒和平衡木实验中未表现出肌松作用，对小鼠自主活动（中央穿格次数、直立、整毛及排便次数）有抑制作用，与戊巴比妥钠有协同作用，可缩短入睡潜伏期，延长睡眠持续时间。经十二指肠给药后，对麻醉犬呼吸幅度、呼吸频率、SBP（收缩压）、DBP（舒张压）、MBP（平均血压）、HR（心率）、T波、P波、PR间期、QRS、QT间期均无明显影响。结论：南五味子软胶囊对小鼠一般行为、运动协调能力以及麻醉犬心血管系统和呼吸系统无明显影响，抑制小鼠自主活动次数，与戊巴比妥钠有协同作用，提示南五味子软胶囊对精神神经系统有一定抑制作用，这与该药镇静安神助眠的药效相符。

Study on General Pharmacology of Nanwuweizi Softcapsule

Objective: To observe the effects of Nanwuweizi softcapsule on nervous system in mice as well as respiration system and cardiovascular system in dogs. Method: Mice were given oral medicine with different doses (100,200,400 mg·kg^-1) of Nanwuweizi softcapsule, and general behavior, spontaneous locomotor test, cooperation movement ability and synergistic effect with pentobarbital-sodium in mice were observed. Anesthetized dog were given Nanwuweizi softcapsule via duodenum with different doses (50,100,200 mg·kg^-1) to observe the effect on respiration system and cardiovascular system in dogs. Result: Nanwuweizi softcapsule had no affect on mice's general behavior, rotating bar and balance beam activity, as well as canine respiration system and cardiovascular system, including frequence and depth of respiration, systolic blood pressure(SBP), diastolic blood pressure(DBP), mean blood pressure(MBP), heat rate(HR), T-wave, P-wave, PR, QRS, QT interval segment of electrocardiogram. It decreased the locomotor activity and had synergistic effect with pentobarbital-sodium in mice with shorter sleep latency and longer sleep lasting time. Conclusion: Nanwuweizi softcapsule had no significant effects on general behavior, cooperation movement ability in mice as well as respiration and cardiovascular system in dogs. Nanwuweizi softcapsule had suppressive effect on spontaneous locomotor test and synergistic effect with pentobarbital-sodium in mice, which was consistent with the hypnagogic activity of Nanwuweizi softcapsule.