| 普伐他汀治疗慢性心力衰竭的临床观察 |
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| 引用本文： | 唐渝平,裴文楠,史若飞,岳瑞华.普伐他汀治疗慢性心力衰竭的临床观察[J].重庆医学,2009,38(18). |
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| 作者姓名： | 唐渝平 裴文楠 史若飞 岳瑞华 |
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| 作者单位： | 重庆市急救医疗中心心血管内科,400014 |
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| 摘 要： | 目的 探讨普伐他汀治疗慢性心力衰竭(CHF)的疗效和安全性以及对CHF患者心室重塑的影响.方法 选择CHF患者130例,随机分为两组.对照组55例,给予强心剂、利尿剂、β-受体阻滞剂、血管紧张素转换酶抑制剂或血管紧张素受体拮抗剂等常规治疗;普伐他汀组(治疗组)75例,在同对照组用药的基础上加用普伐他汀20mg,每日1次口服.每月门诊随访,观察治疗前及治疗后6个月心功能分级、左室射血分数(LVEF)、左室收缩末内径(LVESD)及左室舒张末内径(LVEDD).结果 治疗组在治疗后6个月心功能、LVEF、LVESD、LVEDD较对照组有明显改善,与对照组比较差异有统计学意义,无肝、肾功能异常,肌酸激酶无明显增高.结论 CHF患者在心力衰竭标准治疗的基础上加用普伐他汀20mg/d,治疗6个月,安全、有效,且可改善心功能,改善心室重塑.
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| 关 键 词： | 心力衰竭 充血性 心室重塑 普伐他汀 |
Observation on effect of pravastatin on chronic heart flailure |
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| TANG Yu-ping,PEI Wen-nan,SHI Ruo-fei,et al..Observation on effect of pravastatin on chronic heart flailure[J].Chongqing Medical Journal,2009,38(18). |
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| Authors: | TANG Yu-ping PEI Wen-nan SHI Ruo-fei |
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| Institution: | TANG Yu-ping,PEI Wen-nan,SHI Ruo-fei,et al.(Department of Cardiology,Emergency Medical Center of Chongqing,Chongqing 400014,China) |
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| Abstract: | Objective To investigate the change of cardiac function in the patients with chronic heart failure(CHF) after pravastatin treatment.Methods 130 patients with CHF were randomly divided into two groups:pravastatin group(75patients)and control group(55 patients).The patients in the pravastatin group were given pravastatin 20mg/d for 6-month besides conventional therapy.Echocardiographic indices were evaluated before and after 6-month therapy.Results Pravastatin significantly decreased LV diastolic dimensions a... |
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| Keywords: | heart failure congestive ventricular remodeling pravastatin |
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