性激素受体在肝细胞癌的表达及其临床意义

运用Ｓ－Ｐ免疫组化法对３０例手术治疗的男性肝细胞癌患者癌组织，癌周组织及２０例良性病变肝组织的雄激素受体，雌激素受体以及孕激素受体进行了检测。结果；肝癌组织ＡＲ阳性率８０．０％，显著高于癌周组织及良性病变肝组织，Ｐ〈０．０１，后两者比较无显著性差异；癌组织ＥＲ阳性率为４３．３％，显著低于癌周组织，Ｐ〈０．０１，与良性病变肝组织比较无差异；ＰＲ阳性率在３种组织中比较无显著性差异。

THE EXPRESSION AND CLINICAL SIGNIFICANCE OF SEX HORMONE RECEPTOR IN HEPATOCELLULAR CARCINOMA

The level of androgen receptor (AR), estrogen receptor (ER) and progesterone receptor (PR) of carcinoma and pericarcinoma tissue were determined in 30 cases of male hepatocellular carcinoma (HCC) patients operated by streptavidin peroxdase conjugated method, meanwhile used 20 patients with benign liver disease as a contrast group. The results showed that the positive rate of AR in tumor tisse was 80.0%, significantly higher than that in peritumor tissue (46.7%) and liver tissue of benign diseases (40.0%), P <0.01, and there was no significantly difference between the latter two groups ( P >0.05). The positive rate of ER in carcinoma tissue (43.3%) was notably lower than that in pericarcinoma tissue (80.0%), P <0.01. Statistically significantly difference wasn't achieved in contrast with the benign diseases group (50.0%), P >0.05. The positive rate of PR had no significantly difference among the three groups ( P >0.05). The authors suggest that sex hormone is related to initializing and developing of HCC by the action via its receptor, the level of AR and ER can be used as a prognosis determine index of HCC.