| 在CerbB-2表达不同的乳腺癌组织中Maspin的表达 |
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| 引用本文： | 王留兴,赵培荣,王冰,樊青霞,王瑞林,张国民.在CerbB-2表达不同的乳腺癌组织中Maspin的表达[J].肿瘤基础与临床,2005,18(2):85-86. |
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| 作者姓名： | 王留兴 赵培荣 王冰 樊青霞 王瑞林 张国民 |
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| 作者单位： | 郑州大学肿瘤中心,第一附属医院肿瘤科,河南,郑州,450052;河南大学淮河医院病理科,河南,开封,475000 |
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| 基金项目： | 河南省国际科技合作项目 (0 346630 0 0 7) |
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| 摘 要： | 目的 对CerbB 2表达不同的乳腺癌组织中肿瘤抑制基因Maspin的表达变化进行比较研究。方法 采用免疫组化SP染色法检测2 9例乳腺癌组织中Maspin蛋白的表达情况。结果 Maspin蛋白在CerbB 2阴性表达的乳腺癌组织中的高表达率为47% (7/15 ) ,在CerbB 2阳性表达的乳腺癌组织中的高表达率仅为7% (1/14 ) ,两者有显著性差异(P <0 .0 5 )。结论 在CerbB 2表达不同的乳腺癌组织中Maspin表达亦存在显著差异,Maspin也可作为判定乳腺癌恶性程度及预后的指标。
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| 关 键 词： | 乳腺肿瘤 Maspin CerbB-2 预后 |
| 文章编号： | 1003-1464(2005)02-0085-02 |
| 修稿时间： | 2005年1月12日 |
The Different Expression of Maspin in Human Mammary Cancer of Different CerbB-2 Expression |
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| Wang Liuxing,Zhao Peirong,Wang Bing,Fan Qingxia,Wang Ruilin,Zhang Guomin.The Different Expression of Maspin in Human Mammary Cancer of Different CerbB-2 Expression[J].journal of basic and clinical oncology,2005,18(2):85-86. |
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| Authors: | Wang Liuxing Zhao Peirong Wang Bing Fan Qingxia Wang Ruilin Zhang Guomin |
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| Institution: | Wang Liuxing 1,Zhao Peirong 1,Wang Bing 1,Fan Qingxia 1,Wang Ruilin 1,Zhang Guomin 2 |
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| Abstract: | Objective To investigate the expression of tumor suppressor gene Maspin in human mammary carcinoma of different CerbB-2 expression.Methods Immunohistochemistry method(SP) was used to determine the immunoreactivity of Maspin in 29 cases with mammary cancer.Results The strong positive immunostaining rate of Maspin protein was 47%(7/15) in mammary cancer of CerbB-2 negative expression, but The strong positive immunostaining rate of Maspin protein was 7%(1/14) in mammary cancer of CerbB-2 positive expression. There was a statistically significant association between the two groups (P<0.05).Conclusions There was an obviously different expression of Maspin between mammary cancer of CerbB-2 negative expression and of positive expression. Maspin may be a useful marker for prognosis of mammary cancer. |
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| Keywords: | mammary neoplasms Maspin CerbB-2 prognosis |
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