| 海洛因依赖者外周血淋巴细胞染色体畸变和微核的观察 |
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| 引用本文： | 姚波,蒋本荣,王淑范. 海洛因依赖者外周血淋巴细胞染色体畸变和微核的观察[J]. 中国药物依赖性杂志, 1996, 0(1) |
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| 作者姓名： | 姚波 蒋本荣 王淑范 |
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| 作者单位： | 北京北太平路医院 |
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| 摘 要： | 应用常规染色体畸变分析和胞浆分裂阻滞微核法检测了海洛因依赖者外周血淋巴细胞染色体畸变率和微核率，并将海洛因依赖组微核率和微核细胞率与正常对照相比较。结果表明，海洛因依赖组微核细胞率和微核率显著高于对照，但不能排除吸烟的影响；在海洛因依赖组中所观察到的染色体畸变主要为单间隙．
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| 关 键 词： | 染色体畸变，微核，海洛因依赖 |
THE OBSERVATION OF CHROMOSOME ABERRATIONS ANDMICRONUCLEUS IN LYMPHOCYTES OF HEROIN ADDICTS |
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| Yao Bo, Jiang Benrong, Wang Shufan. THE OBSERVATION OF CHROMOSOME ABERRATIONS ANDMICRONUCLEUS IN LYMPHOCYTES OF HEROIN ADDICTS[J]. Chinese Journal of Drug Dependence, 1996, 0(1) |
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| Authors: | Yao Bo Jiang Benrong Wang Shufan |
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| Abstract: | The frequency of chromosome aberrations and micronucleus in lymphocytes is examined by conventional chromosome aberrations analysis and cytokinesis -- block micronucleus method in heroin addicts. The frequency of micronucleus cellsand micronucleus in heroin addicts is compared with the control. The result showedthat though the frequency of micronucleus cells and micronucleus in heroin addicts wassignificantly higher than that of the control, the effect of smoking could not be excluded. Most chromsome aberrations observed in heroin addicts are of chromatid gap. |
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| Keywords: | chromosome aberration micronucleus heroin addict |
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