| 糖尿病并发心血管疾病的机理研究进展 |
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| 引用本文： | 孙纪新,翟新灵,符云峰. 糖尿病并发心血管疾病的机理研究进展[J]. 心血管病学进展, 2004, 25(4): 299-302 |
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| 作者姓名： | 孙纪新 翟新灵 符云峰 |
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| 作者单位： | 1. 河北省疾病预防控制中心,慢性病防治部,河北,石家庄,050021
2. 河北省疾病预防控制中心,生化研究室,河北,石家庄,050021 |
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| 摘 要： | 心血管疾病 (CVDs)是糖尿病常见的并发症和主要死因。糖尿病并发CVDs的主要危险因素包括 :高血压、肥胖、动脉粥样硬化、脂质代谢失常、微蛋白尿、内皮功能失常、血小板高凝聚性、凝血 血纤溶系统活性失常以及糖尿病心肌病等。本文简要综述了糖尿病患者脂质代谢异常、内皮功能失常、蛋白质非酶糖化、氧化应激等病理生理生化变化促使动脉粥样硬化形成和CVDs发生的分子机理。
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| 关 键 词： | 糖尿病 心血管疾病 并发症 机理 |
| 文章编号： | 1004-3934(2004)04-0299-04 |
| 修稿时间： | 2003-07-15 |
Advances of Research on Pathogenesis of Diabetic Cardiovascular Complications |
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| SUN Ji-xin,ZHAI Xin-ling,FU Yun-feng. Advances of Research on Pathogenesis of Diabetic Cardiovascular Complications[J]. Advances in Cardiovascular Diseases, 2004, 25(4): 299-302 |
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| Authors: | SUN Ji-xin ZHAI Xin-ling FU Yun-feng |
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| Affiliation: | SUN Ji-xin1,ZHAI Xin-ling1,FU Yun-feng2 |
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| Abstract: | Cardiovascular diseases (CVDs) are the major complications and causes of mortality in persons with diabetes,and many factors including hypertension,obesity,atherosclerosis,dyslipidemia,microalbuminuria,endothelial dysfunction,platelet hyperaggregability,coagulation abnormalities,and diabetic cardiomyopathy,contribute to this high prevalence of CVDs.The molecular mechanisms of atherosclerosis,dyslipidemia,and especially endothelial dysfunction,leading to cardiovascular diseases in diabetes are reviewed briefly. |
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| Keywords: | diabetes cardiovascular diseases complication pathogenesis |
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