| 利用组织芯片检测上皮型钙黏素在宫颈癌浸润转移中的作用 |
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| 引用本文： | 李颖,张静,李建民,吴素慧.利用组织芯片检测上皮型钙黏素在宫颈癌浸润转移中的作用[J].山西医科大学学报,2006,37(5):468-469. |
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| 作者姓名： | 李颖 张静 李建民 吴素慧 |
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| 作者单位： | 1. 山西医科大学第一临床医学院妇科,太原,030001
2. 山西省肿瘤医院病理科 |
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| 基金项目： | 山西省太原市科技攻关计划 |
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| 摘 要： | 目的 检测上皮型钙黏素E-cad在宫颈鳞癌中的表达，探讨其在浸润转移中的作用。方法 利用组织芯片的免疫组化染色对10例正常宫颈上皮、63例无淋巴结转移宫颈鳞癌、63例有淋巴结转移宫颈鳞癌组织中E-cad的蛋白表达进行检测。结果E-cad在正常宫颈组织的表达高于宫颈鳞癌P〈0．05，在无淋巴结转移宫颈鳞癌组织显著高于有淋巴结转移组织（P〈0．05），且E-cad的表达与淋巴结转移相关（P〈0．05）。结论 E-cad与宫颈鳞癌的浸润转移密切相关，可用于判断预后及指导临床治疗。
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| 关 键 词： | 宫颈肿瘤 癌 鳞状细胞 钙黏着糖蛋白类 肿瘤转移 寡核苷酸序列分析 |
| 文章编号： | 1007-6611（2006）05-0468-02 |
| 收稿时间： | 2006-03-24 |
| 修稿时间： | 2006-03-24 |
Relation between expression of E-cad and metastasis of cervical squamous carcinoma using tissue chip |
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| LI Ying, ZHANG Jing, LI Jian-min, et al.Relation between expression of E-cad and metastasis of cervical squamous carcinoma using tissue chip[J].Journal of Shanxi Medical University,2006,37(5):468-469. |
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| Authors: | LI Ying ZHANG Jing LI Jian-min |
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| Institution: | Dept of Gynaecology , First Clinical Medical College, Shanxi Medical University, Taiyuan 030001, China |
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| Abstract: | Objective To study the expression of E-cad in cervical squamous carcinoma and its role in metastasis.Methods There were 10 cases of normal cervical tissue,63 cases of cervical squamous carcinoma without lymph node metastasis and 63 cases of cervical squamous carcinoma with lymph node metastasis.Of them the expression of E-cad was researched by immunohistochemistry using tissue chip.Results Ecad expression was higher in normal cervical epithelium than in cervical squamous carcinoma.The E-cad positive rate in patients without lymph nodes metastasis was higher than that in those with lymph nodes metastasis(P<0.05). Conclusion The expression of E-cad has close relationship with lymph node metastasis.Expression of E-cad is important to evaluate the prognosis of cervical cancer. |
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| Keywords: | cervix neoplasms carcinoma squamous cell cadherins neoplasm metastasis oligonudeotide array sequence analysis |
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