川崎病血管内皮功能与血小板激活的相关性及复方丹参滴丸的影响

目的:研究川崎病(Kawasaki disease,KD)患儿血管内皮功能与血小板激活状态的相关性及复方丹参滴丸的影响。方法:KD患儿60例,随机分为丹参治疗组(32例)和普通治疗组(28例)。另35名正常小儿作为对照组。用流式细胞仪检测血小板膜糖蛋白CD62p、CD63的表达,同时用超声诊断仪测定肱动脉直径,计算肱动脉内径舒缩百分率(D％)。结果:KD患儿治疗前、后其CD62p、CD63的表达及D％均分别明显高于,低于对照组(P均<0.01);用复方丹参治疗3个月后CD62p、CD63的表达及D％均分别明显低于,高于治疗前(P<0.01),而普通治疗组治疗前、后各指标均无显著差异(P>0.05)。结论:KD患儿在恢复期血小板活化程度仍明显增高,仍有血管内皮功能障碍;复方丹参滴丸能有效改善之。

Correlativity between vascular endothelial function and platelets activation and the effects of composite dan-shen root dropping pill in treatment of children with Kawasaki disease

Objective: To study the correlativity between vascular endothelial function and platelets activation and the effects of composite dan-shen root dropping pill (CDDP) in treatment of children with Kawasaki disease (KD). Methods: Sixty KD patients were randomly divided into two groups: CDDP treated group (n=32) and general treated group (n = 28). There were 35 heath children as control group. The expression of glycoprotein CD62p, CD63 was measured by flow cytometry. The diameter of brachial arteries (D%) was measured with high-resolution ultrasound system. Results: The expression of CD62p, CD63and D% in KD patients were respectively higher, lower than those of system control group (P<0. 01); In CDDP group, the expression of CD62p, CD63and D% were respectively lower, higher, at 3 months after therapy than those of before. In general treated group, the expression of CD62p, CD63and D% before and after therapy were no significant difference. Conclusion: Platelets are highly activated and there is endothelial-dependent vasodilation dysfunction in convalescent KD patients, it may improve by CDDP.