非甾体抗炎药物在骨性关节炎中的应用

骨性关节炎是老年人中常见、多发的慢性进行性骨关节疾病,主要临床表现为缓慢发展的可使活动受限的关节疼痛、僵硬和肿胀,严重的能导致关节功能障碍.非甾体抗炎药物是目前治疗骨性关节炎等关节炎性疾病的最常用药物,作用机制为抑制环氧化酶活性、阻断该酶催化花生四烯酸转化为炎性物质前列腺素,从而发挥止痛、消炎作用.非甾体抗炎药物分为非选择性环氧化酶抑制剂和选择性环氧化酶-2抑制剂两类,应用广泛,但也存在多种不良反应,故选择用药时要严格掌握适应证,合理用药.

The use of non-steroidal anti-inflammatory drugs in osteoarthritis

Osteoarthritis(OA) is a kind of common and chronic progressing arthritis disease for the elderly.Its main clinical manifestation is progressing chronic arthralgia,rigidity,tumid accompanied with movement restriction,which lead to dysfunction of the knee joint if the condition is serious.Non-steroidal anti-inflammatory drugs(NSAID) is one of the most applied drugs for osteoarthritis and other arthritis diseases,whose mechanism is to inhibit cyclooxygenase activity and block this enzyme to catalyze arachidonic acid to prostaglandin so as to inhibit the inflammatory substance prostaglandin and play the analgesic and anti-inflammatory functions.NSAID is classified into two categories:non-selective cyclooxygenase inhibitor and selective cyclooxygenase-2 inhibitor,which are widely applied,but have a variety of adverse reactions.When choosing a drug for OA,we must strictly control its indications and rationally use it.