胆石病动物模型研究

研究胆石成因和胆石病的防治方法常需制作胆石病动物模型。许多脊椎动物可产生胆石病,但不同种系的动物致石能力不同。运用胆道梗阻感染法、异物核心埋藏法、药物注射法、植物神经刺激法和喂饲法可成功地制作胆石病的动物模型,其中低蛋白饮食喂饲法是诱发胆色素结石的常用方法。近年来已对胆石模型的定向控制技术引起重视,但进展尚少。胆石模型在研究胆石成因、病理和临床治疗上有一定价值。

Research on the animal model of cholelithiasis

An animal model of cholelithiasis is necessary for the research on gallstone formation and treatment of cholelithiasis. Cholelithiasis can be induced in many vertebrate animals and different strains of animals have different capacity to form cholelithiasis. An animal model of cholelithiasis can be established by many procedures, such as biliary obstruction and infection, foreign body core implantation, drug injection, autonomic nerve stimulation, lithogenic diet and so on. Low-protein diet feeding is used mostly to establish an animal model of pigment stone. Recently, more attention has been paid to the directional control in the formation of animal model of cholelithiasis in spite of less progress. The animal model of cholelithiasis does have a role in the study of gallstone formation, pathogenesis and clinical treatment of cholelithiasis.