| 两种痴呆模型鼠脑组织超微结构观察 |
| |
| 引用本文： | 吴洪娟,郭文君,王尊哲,李光宗,李秀艳. 两种痴呆模型鼠脑组织超微结构观察[J]. 中国现代医学杂志, 2003, 13(17): 42-43,46 |
| |
| 作者姓名： | 吴洪娟 郭文君 王尊哲 李光宗 李秀艳 |
| |
| 作者单位： | 1. 潍坊医学院形态学实验室,潍坊,261042
2. 潍坊医学院病理学教研室,潍坊,261042 |
| |
| 摘 要： | 目的：通过对两种方法制备的SD大鼠痴呆模型脑组织超微结构观察，探讨损伤性痴呆模型大鼠脑组织超微结构变化。方法：分别用海人酸破坏脑基底核和电流刺激法制作两种大鼠痴呆模型，并对两种模型的脑组织超微结构进行了观察。结果：二种方法均可致神经细胞、神经胶质细胞浆内线粒体数目减少，嵴断裂或消失，部分线粒体呈空泡状。高尔基氏体增多，呈囊泡状，内质网稀疏并有核糖体脱失，胞浆内脂褐素增多。结论：脑神经细胞的退行性变是痴呆模型的病变基础。
|
| 关 键 词： | 痴呆模型 脑组织 超微结构 动物模型 |
ULTRASTRUCTURE OBSERVATION ON BRAIN TISSUES OF TWO DEMENTIA MOUSE MODELS |
| |
| Wu Hongjuan,Guo Wunjun,Wang Zunzhe,et al. ULTRASTRUCTURE OBSERVATION ON BRAIN TISSUES OF TWO DEMENTIA MOUSE MODELS[J]. China Journal of Modern Medicine, 2003, 13(17): 42-43,46 |
| |
| Authors: | Wu Hongjuan Guo Wunjun Wang Zunzhe et al |
| |
| Affiliation: | Wu Hongjuan,Guo Wunjun,Wang Zunzhe,et al Department of Morphology of Weifang Medical College,Shandong 261042 |
| |
| Abstract: | Objective:To explore the ultrastructure changes of damaged dementia SD rats animal models.Methods:Destroyed basal nuclei by kainic acid and electric stimulate method have established two animal dementia model and observed the ultrastmcture of brain tissue of the models by electro microscope.Results:Two methods can destroyed cell organs of nerve cells and neuroglial cells. Changes are mainly on mitochondria and cell organs. Conclusions:Degeneration of nerve cells was the pathologic basement of animal dementia model. |
| |
| Keywords: | Dementia Brain Ultrastructure Animal Model |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
