Chronic renal failure in Iranian children |
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| Authors: | Kamyar Madani Hassan Otoukesh Asghar Rastegar S. Van Why |
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| Affiliation: | (1) Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA, US;(2) Department of Nephrology, Ali-Asghar Children’s Hospital, Iranian University of Medical Sciences, Teheran, Iran, IR;(3) Department of Pediatrics, Yale University School of Medicine, 333 Cedar Street, PO Box 208064, New Haven, CT 06520-8064, USA e-mail: scott.vanwhy@yale.edu Tel.: +1-203-7854643, Fax: +1-203-7853462, US |
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| Abstract: | We investigated chronic renal failure (CRF) in 166 Iranian children (95 boys and 71 girls) from July 1991 to June 1999. The mean age at onset of CRF was 7.9±4.5 years. The most common cause of CRF was congenital urological malformations (78 cases). The second most common cause of CRF was hereditary nephropathy (21%). Glomerular diseases accounted for only 10% of children who later went on to develop renal failure. High rates of cystinosis and primary hyperoxaluria were seen, and these elevated rates could be due to a high prevalence of parental consanguinity. Eighty-six patients required renal replacement therapy, of whom the majority underwent hemodialysis. The prevalence of primary reflux as a cause of CRF was high compared with reports from western countries. Earlier diagnosis and management of urinary tract infections in this group could reduce the prevalence of reflux as a cause of CRF in this population. Received: 15 May 2000 / Revised: 2 October 2000 / Accepted: 5 October 2000 |
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| Keywords: | Chronic renal failure Etiology Iranian children |
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