脑的转移性和原发性乳头状肿瘤的免疫组织化学研究

对２２例脑内具有乳头状结构的肿瘤（１５例转移癌，５例室管膜瘤和２例脉络丛乳头状瘤）的石蜡切片进行免疫组化染色并结合临床资料研究。使用抗体为ＭＡＫ－６，ＧＦＡＰ，ＶＭ，ＡＡＣＰ和Ｓ－１００，ＭＡＫ－６检查，转移癌有１４例阳必，室管膜瘤１例阳性，而２例脉络丛乳头状瘤均阴性；ＧＦＡＰ检查，转移瘤仅１例阳性，室管膜瘤４例和脉络丛乳头状瘤１例阳性，Ｓ－１００检查，转移瘤３例阳性及全部室管膜瘤和脉络丛乳头状瘤

An immunohistochemical study of primary and metastatic papillary tumors in the brain

Immunohistochemical stains on the paraffin sections of 22 papillary tumors in the brain and their related clinical data were investigated. These tumors included metastatic papillary carcinomas in 15, papillary ependymomas in 5 and choroid plexus papillomas in 2 cases. The panel of antibodies applied consisted of cytokeratin MAK6, glial fibrillary acidic protein (GFAP), vimentin (VM), alpha - antichymotrypsin (AACT) and S - 100 protein (S - 100). In the results of staining for MAK - 6, 14 metastatic carcinomas and 1 ependymoma showed positive,while the 2 choroid plexus papillomas negative; in the staining for GFAP, 1 metastatic carcinoma, 4 ependymomas and 1 choroid plexus papilloma were positive; in the staining for S - 100, 3 metastatic carcinomas and all the ependymomas and choroid plexus papillomas were positive; and in the stainings for VM and AACT, no significant specificity was seen. The results show that MAK - 6, GFAP and S - 100 are important markers for the differentiation between metastatic and primary papillary tumors in the brain. With the use of a panel of these antibodies and the analyses of clinical and light microscopic findings, most of the papillary tumors in the brain can be differentiated.