尿路感染反复发作与机体免疫状态关系的研究

目的探讨尿路感染反复发作与机体免疫状态的关系。方法选取反复发作性和初发性尿路感染患者各 30例 ,正常健康成人 10例作为正常对照。分别检测外周血中T淋巴细胞亚群和尿中分泌型免疫球蛋白A(SIgA)。 结果反复发作性尿路感染患者外周血中CD+ 4 细胞降低 ,CD+ 8细胞正常或升高 ,CD+ 4 /CD+ 8比值降低 ,与正常对照组相比有显著性差异 (P <0 .0 1)。反复发作性患者仍降低 ,而初发性尿路感染患者在感染后第 2周尿中SIgA值明显升高 ,与正常对照组相比有显著性差异 (P <0 .0 1)。结论反复发作性尿路感染患者全身免疫功能紊乱 ,尿路局部粘膜免疫功能低下是反复发作的重要原因。

Study of the relationship between human immune state and recurrent urinary tract infections

Objective To investigate the relationship between recurrent urinary tract infections(RUTI) and immune state. Methods 30 cases with RUTI and with initial onset of UTI were selected respectively. 10 healthy adults were used as normal controls. T lymphocyte subsets in the peripheral blood and the SIgA in urine were detected. Results Among the patients with RUTI, CD + 4T lymphocyte in the peripheral blood decreased; CD + 8T lymphocyte increased or remained normal; CD + 4/CD + 8 ratio decreased. Compared with the normal group, the 30 cases bore significant differences (P<0.01). The SigA in urine decreased on the second week after infection, which were compared with the normal group (P<0.01). Conclusion The important reasons that may cause RUTI are the systemic immune dysfunction and lowered local immune functions in urinary tract.