Severe hyperhomocysteinaemia and 5-oxoprolinuria secondary to antiproliferative and antimicrobial drug treatment |
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| Authors: | B. Schwahn G. Kameda R. Wessalowski E. Mayatepek |
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| Affiliation: | (1) Clinic for General Pediatrics, University Children’s Hospital, Moorenstrasse 5, D-40225 Düsseldorf, Germany;(2) Clinic for Pediatric Oncology, Hematology and Immunology, University Children’s Hospital, Düsseldorf, Germany |
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| Abstract: | Summary A hitherto healthy 7-year-old girl underwent antiproliferative and antibiotic treatment owing to the diagnosis of T-cell lymphoma and concomitant bacterial infection. She developed an encephalopathic crisis associated with metabolic acidosis, hyponatraemia and severe hyperhomocysteinaemia and 5-oxoprolinuria. Laboratory tests normalized completely after recovery. Primary defects in glutathione metabolism could be excluded. |
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