| HSPTX复苏对失血性休克大鼠诱发的急性肺损伤的影响 |
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| 引用本文： | 刘玉,唐季春,谈大海,陈正,张焰,曾因明.HSPTX复苏对失血性休克大鼠诱发的急性肺损伤的影响[J].中国新药杂志,2010(8). |
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| 作者姓名： | 刘玉 唐季春 谈大海 陈正 张焰 曾因明 |
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| 作者单位： | 苏州大学附属第四人民医院麻醉科;江苏省麻醉学重点实验室; |
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| 摘 要： | 目的:探讨HSPTX(7.5%氯化钠+己酮可可碱)复苏对失血性休克大鼠诱发的急性肺损伤的影响。方法:24只雄性SD大鼠随机分为3组:假失血性休克(Sham)组,乳酸钠林格液(Ringer′s lactate,RL)复苏组,HS+PTX复苏组,每组8只。实验结束时测定各组大鼠肺水含量、支气管肺泡灌洗液(bronchoalveolor lavage fluid,BALF)中中性粒细胞(polymorphonuclear neutrophil,PMN)百分比和总蛋白(total protein,TP)浓度;测定肺组织髓过氧化物酶(myeloperoxidase,MPO)活性,检测肺组织中丙二醛(malondialdehyde,MDA)以及超氧化物歧化酶(superoxide dismutase,SOD)含量;ELISA法测定血浆中肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)、白细胞介素1β(interleukin1β,IL-1β)含量。结果:与Sham组相比,各实验组休克复苏2 h后肺水含量、总蛋白含量、PMN百分比、血浆中TNF-α、IL-1β表达以及肺组织MDA,MPO含量明显增...
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| 关 键 词： | 己酮可可碱 肺损伤 髓过氧化酶 超氧化物歧化酶 丙二醛 |
Effects of resuscitation with hypertonic saline and pentoxifylline on hemorrhagic shock-induced acute lung injury in rats |
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| LIU Yu,TANG Ji-chun,TAN Da-hai,CHEN Zheng,ZHANG Yan,ZENG Yin-ming.Effects of resuscitation with hypertonic saline and pentoxifylline on hemorrhagic shock-induced acute lung injury in rats[J].Chinese Journal of New Drugs,2010(8). |
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| Authors: | LIU Yu TANG Ji-chun TAN Da-hai CHEN Zheng ZHANG Yan ZENG Yin-ming |
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| Institution: | LIU Yu1,2,TANG Ji-chun1,TAN Da-hai1,CHEN Zheng1,ZHANG Yan1,ZENG Yin-ming2(1 Department of Anesthesiology,the Fourth Affiliated Hospital,Suzhou University,Wuxi 214062,China,2 Jiangsu Provincial Key Laboratory of Anesthesiology,Xuzhou 221002,China) |
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| Abstract: | |
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| Keywords: | pentoxifylline lung injury myeloperoxidase superoxide dismutase malondialdehyde |
| 本文献已被 CNKI 等数据库收录！ |
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