| p38丝裂原活化蛋白激酶信号通路对胰岛素作用的研究进展 |
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| 引用本文： | 贺钰梅.p38丝裂原活化蛋白激酶信号通路对胰岛素作用的研究进展[J].医学综述,2010,16(19). |
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| 作者姓名： | 贺钰梅 |
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| 作者单位： | 广西医科大学第一附属医院代谢糖尿病中心,南宁,530021 |
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| 基金项目： | 广西自然科学基金，广西医疗卫生自筹经费计划课题 |
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| 摘 要： | 丝裂原活化蛋白激酶(MAPK)在哺乳动物细胞多种信号转导通路中起重要作用,p38MAPK作为其成员之一,可以调节细胞的多种生物学反应,在2型糖尿病胰岛素分泌和胰岛素抵抗发病机制中有重要的作用。p38δ-蛋白激酶D通路综合调节胰岛素分泌能力和胰腺β细胞的存活,p38 MAPK信号通路通过炎性因子、游离脂肪酸、氧化应激等对脂肪、骨骼肌作用,参与胰岛素抵抗。
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| 关 键 词： | p38丝裂原活化蛋白激酶 糖尿病 胰岛素分泌 胰岛素抵抗 |
Recent Progress in Research on the p38 MAPK Cell Signal Pathway in Insulin |
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| HE Yu-mei.Recent Progress in Research on the p38 MAPK Cell Signal Pathway in Insulin[J].Medical Recapitulate,2010,16(19). |
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| Authors: | HE Yu-mei |
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| Institution: | HE Yu-mei,XIAO Chang-qing,PANG Cui-jun.(Center of Metabolic Disease and Diabetes Mellitus,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China) |
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| Abstract: | Mitogen-activated protein kinase,is widely expressed in mammalian cells,which plays an important role in a variety of signal transduction pathways.p38 is one member of the MAPkinase family,can adjust the biological reaction of cells,as well as plays an important role in the pathogenesis of type 2 diabetes on insulin secretion and insulin resistance.The p38δ fine-tunes protein kinase D-mediated insulin secretion pathway integrates regulation of the insulin secretory capacity and survival of pancreatic β cells,p38 MAPK signaling pathways participate in insulin resistance through inflammatory factors,free fatty acids,oxidative stress in fat and skeletal muscle cells. |
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| Keywords: | p38 Mitogen-activated protein kinase Diabetes Insulin secretion Insulin resistance |
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