Sebaceous gland metaplasia in cardiac-type mucosa of the oesophago-gastric junction |
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| Authors: | R. Kushima F. Borchard G. von Hinüber W. Lessel M. Stolte |
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| Affiliation: | (1) Institute of Pathology, Heinrich Heine University, Moorenstrasse 5, D-40225 Düsseldorf, Germany;(2) Gemeinschaftspraxis Pathologie, Kempten, Germany;(3) Institute of Pathology, Klinikum Bayreuth, Bayreuth, Germany;(4) Shiga University of Medical Science, Ohtsu, Japan |
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| Abstract: | The first case of sebaceous gland metaplasia arising in cardiac-type mucosa of the oesophago-gastric junction of 71-year-old man is reported. Within cardiac glands, small nests composed of clear cells closely resembling sebaceous glands of the skin were found. Immunohistochemically, the cell nests stained positively for a monoclonal antibody 115D8 against milk-fat globule membrane (MAM-6). These cells were sometimes covered by cylindrical cells positive for foveolar-type mucin of the stomach (M1), and basal marginal cells of these nests expressed high molecular weight cytokeratins (34BE12). This study documents a new type of metaplasia of the gastric mucosa. |
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| Keywords: | Sebaceous gland Stomach Oesophagus Metaplasia |
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