肿瘤免疫编辑研究进展

在肿瘤发生发展的过程中,机体免疫系统与肿瘤细胞相互作用,相互编辑.免疫系统的监视作用可清除肿瘤或抑制肿瘤的发生发展,同时免疫系统又可对肿瘤细胞进行重塑,使肿瘤发生免疫逃逸.而肿瘤可诱发机体抗肿瘤的固有及获得性免疫应答,同时也可改变免疫系统的抗肿瘤效应.了解肿瘤免疫编辑的相关研究进展可以为肿瘤防治提供参考.

Progress on cancer immunoediting

During the development of tumors, interaction and editing occur between immune system and tumor cells. Tumor cells could be eradicated or tumor developments could be inhibited because of the surveillance role of immune system, while immune escape may occur for tumor cells remodeled by immune system. Tumors can induce innate and adaptive immune responses as well alter the anti-tumor effect of the immune system. This re-view will summarizes the development of researches in cancer immunoediting in order to insights references for tumor therapy.