| 红花中抗氧化活性成分及其作用机制的研究进展 |
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| 引用本文： | 李娅兰,白皓天,梁霄,张筠昊,孙淑慧,杨婧,王锐. 红花中抗氧化活性成分及其作用机制的研究进展[J]. 现代药物与临床, 2022, 37(8): 1879-1885 |
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| 作者姓名： | 李娅兰 白皓天 梁霄 张筠昊 孙淑慧 杨婧 王锐 |
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| 作者单位： | 黑龙江中医药大学药学院, 黑龙江 哈尔滨 150040;黑龙江中医药大学基础医学院, 黑龙江 哈尔滨 150040 |
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| 基金项目： | 国家自然科学基金资助项目(81603418);黑龙江省自然科学基金面上资助项目(H201472) |
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| 摘 要： | 红花为菊科植物红花的干燥管状花，为活血化瘀类中药，临床上多用于治疗心脑血管疾病。适宜的抗氧化物质可以有效地消除过多自由基，对于各种氧化应激相关疾病的治疗具有重要意义。归纳了红花中的抗氧化活性成分黄酮类、多糖类和生物碱类成分，并对其抗氧化酶、清除自由基、拮抗一氧化氮的作用机制进行总结，以期为红花更好的临床应用提供参考。
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| 关 键 词： | 红花 黄酮 山柰酚糖苷 羟基红花黄色素A 多糖 生物碱 抗氧化 抗氧化酶 清除自由基 拮抗一氧化氮 |
| 收稿时间： | 2022-04-09 |
Research progress on antioxidant active components in Carthami Flos and its mechanism |
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| LI Ya-lan,BAI Hao-tian,LIANG Xiao,ZHANG Jun-hao,SUN Shu-hui,YANG Jing,WANG Rui. Research progress on antioxidant active components in Carthami Flos and its mechanism[J]. Drugs & Clinic, 2022, 37(8): 1879-1885 |
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| Authors: | LI Ya-lan BAI Hao-tian LIANG Xiao ZHANG Jun-hao SUN Shu-hui YANG Jing WANG Rui |
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| Affiliation: | Scholl of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150040, China;Basic Medical College, Heilongjiang University of Chinese Medicine, Harbin 150040, China |
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| Abstract: | Carthami Flos is derived from the dry tubular flowers of Carthamus tinctorius Linn. It is a traditional Chinese medicine for promoting blood circulation and removing blood stasis, and was used clinically in treatment of cardiovascular and cerebrovascular diseases. Appropriate antioxidant substances can effectively eliminate excessive free radicals, which is of great significance for the treatment of various oxidative stress-related diseases. This paper describes the antioxidant active components of flavonoids, polysaccharides, and alkaloids in Carthami Flos, and summarizes the mechanism of antioxidant enzymes, scavenging free radicals, and antagonizing nitric oxide, to provide reference for clinical application. |
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| Keywords: | Carthami Flos flavonoid kaempferol glycoside hydroxysafflor yellow A polysaccharide alkaloid antioxidant activity antioxidant enzymes scavenge free radical antagonizing nitric oxide |
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