贲门失弛缓症的诊断与治疗研究进展

贲门失弛缓症(AC)作为原发性食管动力障碍性疾病的一种,以食管下段括约肌松弛功能受损、食管蠕动减弱或消失为主要特征,年发病率为1/100 000~3/100 000,临床表现以吞咽困难最为常见。食管测压法为其诊断金标准,另外还有内镜检查、食管钡餐造影检查等诊断方法。目前发病机制尚未明确,临床上可通过药物治疗、肉毒杆菌毒素注射、气囊扩张术、食管支架植入术、腹腔镜下Heller肌切开术、经口内镜下肌切开术等进行治疗。

Research progress on diagnosis and treatment of achalasia

Achalasia(AC)is a primary esophageal motility disorder characterized by impaired relaxation of the lower esophageal sphincter and absent or decreased peristalsis of the esophageal which annual incidence is about 1/100000-3/100000.The most common clinical manifestation of AC is dysphagia.At present,the esophageal manometry has become the gold standard for the diagnosis of AC.In addition,diagnostic methods of AC include endoscopy and X-ray barium meal.The pathogenesis of achalasia is not fully clarified,treatment modalities include pharmacological therapy,botulinum toxin injection,balloon dilatation,esophageal stents therapy,laparoscopic Heller myotomy,and per-oral endoscopic myotomy.