干细胞源性外泌体在损伤修复中作用的研究进展

器官和组织发生损伤后,干细胞自身的增殖与分化在损伤修复中只发挥很少一部分作用,其修复作用主要是通过干细胞旁分泌功能发挥.外泌体是以胞吐方式分泌到细胞外的纳米级囊泡,靶细胞吸收外泌体后其自身功能会受到调节.干细胞源性外泌体通过传递蛋白质、脂质和微小RNA(miRNA)实现细胞间的通讯.干细胞源性外泌体的靶向性和生物学特性...

Research progress of stem cell-derived exosomes in injury repair

After organ and tissue injury,the proliferation and differentiation of stem cells themselves play only a small role in the repair of injury,and their repair function is mainly played by the paracrine function of stem cells.Exosomes are nano-scale vesicles that are secreted out of the cell by exocytosis.After target cells absorb exosomes,their own functions will be regulated.Stem cell-derived exosomes achieve intercellular communication by delivering proteins,lipids,and microRNA(miRNA).The targeting and biological characteristics of stem cell-derived exosomes are determined by the level of miRNA that they carry.After the exosomes reach the target cells and undergo fusion,they are degraded and then expressed to change the gene expression of the target cells.In addition,the RNA and protein of stem cell-derived exosomes can also limit the development of damage through cell homing.This article will review the mechanism of stem cell-derived exosomes in wound healing,joint injury,fracture healing and heart injury.