虎杖苷在心脑血管系统的药理研究进展

虎杖苷,又名白藜芦醇苷,现代药理学研究发现虎杖苷具有多种药理活性,尤其对心脑血管系统,可以通过改善血液流变学、抗血栓形成、抗氧化、影响离子通道、调节蛋白激酶和一氧化氮等方式,发挥抗心肌缺血/再灌注损伤、保护心肌、抗脑出血以及改善学习记忆力等作用,显示出重要的临床应用价值,深受国内外学者关注。在此对近年虎杖苷在心脑血管系统方面的药理作用及机制研究进行综述。

Progress in Pharmacological Study of Polydatin in Cardio-cerebrovascular System

Polydatin is one of the hydroxy-diphenyl ethylene compounds isolated from traditional Chinese medicine,Polygonum cuspidatum Sieb.et Zucc.Modern pharmacological studies have demonstrated that polydatin has multiple biological activities and important clinical value,drawing much attention from both domestic and oversea research fields,especially for the cardio-cerebrovascular system such as anti-myocardial ischemia-reperfusion injury,anti-cerebral hemorrhage and improve learning and memory through manners such as improving hemorheology,antithrombotic,antioxidant,affecting ion channels,regulating protein kinase and nitric oxide etc..Herre is to make a review over the research on pharmacological effects on cardio-cerebrovascular system of polydatin and its relative mechanisms.